Countries around the world are concentrating resources to jointly fight against the COVID-19 pandemic ; when our bodies face the invasion of foreign viruses , we will also concentrate resources to fight an immune battle against the virus. In addition to being the source of our life , NAD+ provides energy for cells to maintain normal operation and repair genetic damage ; recent clinical studies have shown that NAD+ also enables cells to have sufficient toughness ( cell resilience ) to resist foreign virus infections , reducing the impact of foreign viruses bodily harm.
The study found in cells and animal tissues infected by coronavirus and COVID-19 virus that the attack of COVID-19 virus on cells will cause a rapid decline in NAD+ levels, and at the same time trigger a strong demand for NAD+ in the body to resist the invasion of foreign viruses. Studies have found that supplementing NAD+ levels in the body can enhance the body's immunity to coronavirus and other viral infections. Infected cells will continue to consume NAD+ in order to resist the virus; and the virus will also try to hinder the body's immune resistance and multiply the virus through another set of genes.
The study was jointly conducted by three universities in the United States, University of Iowa, Oregon Health & Science University and University of Kansas, and found that coronaviruses including SARS-CoV-2 and COVID-19 can greatly interfere with the balance of NAD+ in the body. Coronaviruses use multiple different sets of PARP genes to deplete and suppress normal NAD+ levels in the human body, and NAD+ is an important part of maintaining innate immune responses and fighting viruses. In the lung tissue of people who unfortunately died of COVID-19, it can be seen that the coronavirus causes NAD+ to drop sharply, preventing the body from producing more NAD+ and weakening the body's ability to fight the virus; in other words, let us resist external pressure (a variety of physiological stresses) Incapacitated immune mechanisms including viral infections. No amount of research will follow as the data show that preventing NAD+ depletion, or increasing NAD+ levels in the body, can be of great help to cells. In addition to hijacking our immune mechanism, the COVID-19 coronavirus will release a large number of pro-inflammatory molecules (pro-inflammatory molecules) to attack the lungs in the middle and later stages, causing some patients to develop fatal acute respiratory distress syndrome symptoms. Studies have shown that NAD+ plays a very important role in balancing the immune system, regulating sirtuins, coordinating pro-inflammatory molecules and other signal transmission channels.
On April 20, 2020, Dr. Robert J. Huizenga, Cedars-Sinai Medical Center, a medical institution in Los Angeles, USA, published a medical report on the treatment of a patient diagnosed with severe COVID-19. The patient showed significant clinical improvement after receiving oral NMN treatment. 11 days after the diagnosis, the patient developed severe inflammation, dyspnea, and needed to use a breathing apparatus, and his life was in danger. He was immediately sent to the above-mentioned hospital. The doctor prescribed NMN treatment for two consecutive days, and successfully improved his breathing problems and increased the white blood cell content in his body within 12 hours; at 36 Hours later, the patient's blood oxygen content and body temperature returned to normal levels, and the inflammation gradually subsided. The patient was discharged on the 17th day and fully recovered on the 23rd day. NMN treatment for two other elderly patients diagnosed with COVID-19 also recorded significant clinical improvement in fever, chest pressure, cough, headache, low energy and other problems within 36-48 hours. For details, please refer to the original English medical report <here> .
The report concludes: NMN directly supplements NAD+ levels in the body, which can slow down aging-related tissue/organ function decline, enhance immunity, regulate the danger of immune cell overreaction-cytokine storm, promote blood circulation, protect kidneys, The liver and brain are affected by the disease, and NMN has shown significant positive clinical therapeutic effects.
Listen to Prof. David Sinclair personally explaining the key to NMN/NAD+ enhancing immunity and defeating Covid-19; In addition to the research of the above three universities and the medical reports of real Covid-19 patients , please refer to the relevant medical literature <here> .
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Excerpted from the original <hereby> medical literature:
Thus, during aging, a decline in NAD+ and the known mislocalization of SIRT1 and SIRT6 across the genome during aging [68, 109], could be major contributors to the age-dependency of COVID-19 symptoms. Given the increasing evidence that lower NAD+ levels in the lung and vascular endothelium contribute to poor COVID-19 outcomes, NAD boosters, such as the NAD+ precursors NMN and NR , have been suggested as first-line treatments against COVID-19, Especially aged patients . As more and more evidence shows the relationship between low NAD+ level in the body and COVID-19 damage to the body, NAD booster, NAD+ precursor, NMN and NR, are all used to treat COVID-19 patients, especially Is an elderly patient (low NAD+ level in the body).
In addition, supplementing NAD+ cannot be supplemented by taking NAD+ directly. For details, please refer to < this article >. NAD+ can only be supplemented through NAD+ booster precursors NMN and NR, readers are advised to choose NAD+ supplements carefully. Products on the market claiming that NAD+ can directly increase the level of NAD+ than NMN and NR are believed to have violated the <Trade Descriptions Ordinance> unfair trade practices.
What is NAD+?
The full name of NAD+ is Nicotinamide Adenine Dinucleotide, which is a naturally occurring substance in the body that all living things are born with. NAD+ plays an indispensable role in the body, as fuel for all cells, responsible for producing energy, activating longevity gene sirtuins, repairing cell genetic damage, coordinating multiple anti-aging-related epigenetic information transmission channels, reducing inflammation and maintaining all Mechanism balance and so on. The NAD+ level in the body is very high in children and young people, and the NAD+ level in the middle-aged and old people will decrease significantly with age.
Can the NAD+ level in the body be increased?
NAD+ can be supplemented by oral NAD+ precursor NMN. In the human body, NAD+ is derived from Nicotinamide Mononucleotide (NMN). Supplementing NMN in the body is the safest, direct and effective way to increase the level of NAD+ in the body. Detailed information can be found <here> .
If you want to know more or purchase Chuanyu NMN, please feel free to contact us at (852) 84814841 or .
- Huizenga, Robert, Dramatic Cytokine Storm Reversal with an Over the Counter NMN Cocktail (April 20, 2020).
- Heer, CD, et al., Coronavirus Infection and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity. bioRxiv, 2020: p. 2020.04.17.047480.
- Wang, X., et al., Sirtuins and Immuno-Metabolism of Sepsis. Int J Mol Sci, 2018. 19(9).
- Kouhpayeh, S., et al., The Molecular Story of COVID-19; NAD+ Depletion Addresses All Questions in this Infection. Preprints, 2020.
- Shi, Y., et al., COVID-19 infection: the perspectives on immune responses. Cell Death Differ, 2020.
Anyone who needs Chuanyu NMN can also refer to it.